Beyond Topicals: The Science of Skin Longevity ft. JUNG+ founder Simon Sakhai — E.710

A New Frontier in Skin Longevity: Inside-Out Approaches with Jung+Longevity

In a recent episode of Skin Anarchy, host Dr. Ekta welcomed Simon Sakhai, founder of Jung+ Longevity, to dive deep into the emerging science of skin longevity. Departing from conventional cosmetic anti-aging claims, Simon’s approach weaves together cutting-edge longevity research, systemic health principles, and integrative strategies to redefine how we think about preserving and enhancing skin health over time.

From Sleep Science to Longevity Pioneer

Simon’s journey into longevity science began unexpectedly. Initially immersed in sleep diagnostics and research at Oxford, a single lecture on aging mechanisms sparked a fascination that would change his career path. As he learned about the newly defined “hallmarks of aging” — core biological mechanisms driving age-related decline — he recognized their implications for skin health. This shift from sleep studies to tackling age at its biological roots set the stage for Jung+ Longevity’s creation.

“If we know what drives aging, we can actually start to solve it.”

Understanding the Hallmarks of Aging and Skin

A central theme of Simon’s work revolves around the “hallmarks of aging”: once theoretical, now practically applicable targets for improving longevity. Traditionally, skincare has focused largely on surface-level aesthetics — hydration, smoothing fine lines, evening tone — without addressing underlying biological shifts that cause long-term damage.

Key hallmarks influencing skin include:

• Chronic Inflammation: Persistent inflammatory states accelerate cellular damage in skin and throughout the body.
• Senescent Cells: Dubbed “zombie cells,” these refuse to die and secrete harmful signals that induce more widespread aging. Skin, exposed to the environment, is the body’s largest source of senescent cells.
• NAD Decline: NAD, essential for energy and cellular repair, wanes with age, undermining cell function and resilience.
• DNA Damage: UV exposure and environmental stressors harm DNA, reducing skin’s regenerative capacity over time.

By targeting these root causes, we transcend cosmetic quick fixes. Instead, we aim to restore skin’s natural regenerative potential, slow systemic aging, and improve overall vitality.

Skin as a Gateway to Systemic Aging

The conversation underscored a pivotal concept: skin is not an isolated organ. Constantly bombarded by environmental stressors — UV rays, pollutants, pathogens — skin endures ongoing damage. Over time, this damage translates into senescent cell accumulation and inflammation, contributing not just to wrinkles and loss of elasticity, but also fueling aging in other organs.

“Your skin’s senescent cells can travel beyond the epidermis. They affect your entire body.”

Beyond Topicals: The Limits of Surface Solutions

Most skincare solutions, particularly “anti-aging” creams, primarily address superficial moisture and external symptoms. Yet the hallmarks of aging reside deep within cells and tissues, inaccessible by many conventional ingredients. Large molecule sizes — like collagen or elastin — cannot penetrate beyond the outermost dead layer of the epidermis.

To truly influence skin longevity, Simon advocates a more integrated approach — one that involves carefully selected supplements and lifestyle changes. For example:

• Senescent cell clearance: Compounds like spermidine, quercetin, and polyphenols help remove these zombie cells systemically.
• NAD restoration: Nutrients like niacinamide can boost NAD levels for improved cellular energy and better skin function.
• Inflammation reduction: Anti-inflammatory compounds balance immune responses, preserving collagen, elastin, and hyaluronic acid production.

Inside-Out Strategies for Real Results

The hallmark-based approach — aligning targeted interventions with root causes — promises to move the industry beyond guesswork and superficial fixes. By incorporating scientifically supported supplements that bolster cellular health, skin can regain youthful resilience from the inside out.

“This isn’t just about looking younger. It’s about restoring the cellular environment so skin ages more slowly and healthfully.”

A Future of Integrated Skin Health

Jung+ Longevity’s model exemplifies the future of dermal longevity: no longer relying solely on lotions that mimic temporary plumpness, but rather on systemic solutions and validated interventions. By acknowledging skin as both a barrier organ and an essential player in whole-body aging, new possibilities emerge. Consumers can look beyond symptomatic relief, embracing nutritional supplements, lifestyle modifications, and carefully formulated interventions that address fundamental hallmarks of aging.

Ultimately, Simon’s work and Jung+ Longevity’s offerings suggest a paradigm shift: from topical band-aids to genuine cellular rejuvenation. This inside-out approach aligns with cutting-edge science and may set a new gold standard in skincare — one where we truly understand what drives aging and learn to slow it at its biological roots.

To learn more about Jung+ Longevity, visit their website and social media. Don’t forget to subscribe to Skincare Anarchy on Apple Podcasts, Spotify, or your preferred platform. Reach out to us through email with any questions.

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